NMII has two main isoforms, NMIIA and NMIIB, with distinctly different properties. The intracellular force is generated by nonmuscle myosin II (NMII), which is ubiquitously expressed in eukaryotic cells ( Vicente-Manzanares et al., 2009).
In migrating cells, adhesion complexes are established under the influence of tension and coordinate traction for cell propulsion. Maintenance of cell polarity and cell-cell and cell-matrix contacts requires continuous tension. Many fundamental processes in cells such as adhesion, migration, and proliferation are force dependent.
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